Rotavirus is the single most important pathogen in severe dehydrating diarrhea affecting young children. In developing countries, diarrhea is the leading cause of childhood death, killing 5-10 million annually; of which rotavirus causes 440,000 deaths. In this trial involving 238 children under the age of 5, it was found that 100mg of lactoferrin daily for 12 weeks did not significantly reduce the incidence of rotavirus-induced gastroenteritis (5.1% in control vs 4.4% in treated group). However, lactoferrin did significantly reduce the frequency and duration of both vomiting and diarrhea (all P<0.05). 2 children in the control group were so severely dehydrated from diarrhea that they had to be hospitalized but none in the treatment group had such severe symptoms. Thus bovine lactoferrin may be beneficial in reducing the frequency and duration of vomiting and diarrhea from rotaviral gastroenteritis.
PM IIplus consists of 200mg of Lactoferrin in a chewable dosage form. For more information please click here.
Egashira, M., et al., Does daily intake of bovine lactoferrin-containing products ameliorate rotaviral gastroenteritis? Acta Paediatr, 2007. 96(8): p. 1242-4.